The following reasons may be the cause of the software freezing
- The computer is equipped with less RAM than the recommended 16GB.
- Simultaneous loading many .loom files (5+) and / or large .loom files (500MB+).
- Advanced Filter settings changed such that many variants (200+) are included for downstream analysis, e.g., Rare Variant filter changed from default 1 % to < 0.2 % value.
- Use a computer with at least 16GB RAM.
- Load .loom files one at a time.
- Wait until automated data filtering completes.
- Reduce the number of variants in the Advanced Filter parameters.