Tapestri Insights v3.0.2 3 December 2020 Highlights
- Fixed the link to the Walkthrough
- Updated to run on macOS 11.0 (Big Sur)
Tapestri Insights v3.0 29 October 2020 Key Highlights
- DNA + Protein analysis
- Import multi-sample .h5 files instead of .loom files, which are actually .h5 files
- Include more visualizations – UMAP plot, XY plot, and Violin plot
Specific improvements include
- Changed the workflow from Load Samples, Review Variants, Review Subclones to Filter and Explore
- Added an XY (scatter) plot visualization with k-means clustering over VAF (variant allele frequency) and NGT (numbered genotype) and with variant VAF and NGT score view
- Allow the manual selection of the variants and proteins used for analysis
- Added p-values for proteins, calculated using a t-test on the normalized expression
- Added a new feature score for DNA, which is the maximum of the difference in median values between pairwise combinations of clusters
- Added new methods for clustering – DBScan (density-based spatial clustering of applications with noise) and Louvain
- Added asinh (inverse hyperbolic sine function) and CLR (centered log ratio) normalization methods for protein data
- Changed the AF (allele frequency) filter for mutations, only filtering HETs that fall outside the range
- Removed the Summary Report .pdf, Heat Map, and .tap files