Tapestri Insights v3.0.2 3 December 2020 Highlights
Fixed the link to the Walkthrough
Updated to run on macOS 11.0 (Big Sur)
Tapestri Insights v3.0 29 October 2020 Key Highlights
DNA + Protein analysis
Import multi-sample .h5 files instead of .loom files, which are actually .h5 files
Include more visualizations – UMAP plot, XY plot, and Violin plot
Specific improvements include
Changed the workflow from Load Samples, Review Variants, Review Subclones to Filter and Explore
Added an XY (scatter) plot visualization with k-means clustering over VAF (variant allele frequency) and NGT (numbered genotype) and with variant VAF and NGT score view
Allow the manual selection of the variants and proteins used for analysis
Added p-values for proteins, calculated using a t-test on the normalized expression
Added new feature score for DNA, which is the maximum of the difference in median values between pairwise combinations of clusters
Added new methods for clustering – DBScan (density-based spatial clustering of applications with noise) and Louvain
Added asinh (inverse hyperbolic sine function) and CLR (centered log ratio) normalization methods for protein data
Changed the AF (allele frequency) filter for mutations, only filtering HETs that fall outside the range
Removed the Summary Report .pdf, Heat Map, and .tap files