Through a seamlessly integrated workflow, the assay allows researchers to:
- Detect DNA variants (SNVs and indels) in single cells with a sensitivity of 0.1%.
- Reveal clonal architecture (co-occurrence and zygosity of mutations) and uncover the order of acquisition of mutations (phylogeny).
- Identify immunophenotypic signatures (surface protein abundance) and how these differ between clones.
- Track clonal dynamics and immunophenotypic drifts through time course samples to identify clonal evolution.
- Generate comprehensive reports for each sample, including QC metrics and visualizations of results.
- Multiplex up to three samples based on different genotype profiles, with automated demultiplexing and individual report generation.