When should I generate a ‘BE’ report versus a ‘KO’ report?

The report type can be decided based on the following:

1. The Base Editing (BE) Report should be selected for experiments in which a base editor was used to make single base substitutions in cells. The report shows SNVs within the on-target activity window for one or multiple on-targets and shows SNVs and indels for predicted off-target edits. The report does not display indel information in the on-target activity window(s), but this information is accessible in the h5 file.
2. The Knockout (KO) Report should be selected for experiments in which a genome editor (e.g., CRISPR/Cas9) was used to make edits to cells and the intended edit type is indels (i.e, NHEJ repair pathway). The report shows indels observed at one or multiple on-target locations as well as for predicted off-target locations. The report does not display SNV information in the on-target activity window(s), but this information is accessible in the h5 file.
3. In cases where both Report Types are desired, please contact support(support@missionbio.com).